The mandate of IC@L is to establish itself as a nationally leading and internationally recognized research unit focusing on the science of computing and its realization to enable novel solutions and technologies. The future of many disciplines depends on advances in computational science via theoretical and empirical research, and hardware and software development. IC@L joins computational scientists with hospitals, industry and government to address the next generation of computational problems. It addresses critical issues for a knowledge society and advances problem solving in areas such as health, environment, and business.